The Stuart River is a river in northeastern British Columbia, Canada. The river flows over 110 kilometres (68 mi) from Stuart Lake to its junction with the Nechako River. The river drains a portion of the Nechako Plateau — a gently-rolling region characterized by small lakes and tributaries. Low but impressive ridges interact with the river, creating high bluffs and hoodoos.
The Stuart River is important in British Columbia history, having been the conduit for Simon Fraser's expedition down the Fraser River to present-day Vancouver in 1808. It was first ascended by Fraser's assistant, James McDougall, in 1806. The river and the lake it drains are named for another of Fraser's assistants, John Stuart.
During the Omineca Gold Rush, steamboats ran on the river from the Quesnel area on the Fraser River to Stuart Lake.
The river has been named as one of twenty British Columbia heritage rivers.